AstraZeneca’s vaccine ready for use at the vaccination centre in Apolda, Germany, Sunday, Feb. 28, 2021. THE CANADIAN PRESS/Michael Reichel/dpa via AP

AstraZeneca’s vaccine ready for use at the vaccination centre in Apolda, Germany, Sunday, Feb. 28, 2021. THE CANADIAN PRESS/Michael Reichel/dpa via AP

National panel advises against using Oxford-AstraZeneca’s COVID-19 vaccine on seniors

NACI panel said vaccines from Pfizer and Moderna are preferred for seniors ‘due to suggested superior efficacy’

A national panel of vaccine experts says provinces should not use the Oxford-AstraZeneca COVID-19 vaccine on seniors, opening the door for provinces to start vaccinating younger populations with the newly authorized vaccine much earlier than expected.

But similar advice initially issued in Europe began to be revisited Monday, with France overturning its earlier decision against using it on seniors, and Germany in the midst of reconsidering it.

The Oxford-AstraZeneca vaccine was authorized for use Friday on all adults, including seniors, but the National Advisory Committee on Immunization is concerned there is limited data on how well the vaccine will work in older populations.

There are no concerns that the vaccine is unsafe for use, but the NACI panel said in its recommendations the mRNA vaccines from Pfizer-BioNTech and Moderna are preferred for people 65 years old and above “due to suggested superior efficacy.”

NACI says Oxford-AstraZeneca should be offered to people under 65 as long as the benefits of getting a good vaccine earlier outweigh any limitations the vaccine may have in terms of effectiveness.

Individuals should be made aware of those limitations and how long they might otherwise wait for an mRNA vaccine, the advice says.

The panel’s advice helps provincial governments determine how best to use the vaccines available to them, but provinces can make their own calls about what to do.

It will now be up to provinces to determine if they open up vaccinations with Oxford-AstraZeneca to individuals under the age of 65.

Until now, provinces have not anticipated expanding the vaccination campaign to include people younger than that for several more months, most in what they call Phase 2 or even Phase 3, of their vaccine program.

Alberta Health Minister Tyler Shandro said the provincial government has decided to follow NACI’s advice and not give Oxford-AstraZeneca to anyone over the age of 65.

“How that’s going to change the administration of those who are in Phase 2 is still to be determined,” he said. “We’ll be making those decisions and announcing them fairly soon.”

The NACI advice follows similar plans in many European countries. The European Medicines Agency said the vaccine could be used on all adults, but a number of countries decided not to use it for seniors because of the limited clinical data.

However, France reversed course Monday, with French Health Minister Olivier Véran saying Oxford-AstraZeneca was, along with Pfizer-BioNTech and Moderna, remarkably effective against COVID-19.

A study released last week by Public Health Scotland, where the Oxford-AstraZeneca vaccine has been in use since Dec. 30, found COVID-19-related hospital admissions among seniors fell 94 per cent after getting the vaccine.

Nearly 500,000 people in the study had received the Oxford-AstraZeneca vaccine, most of them over the age of 80.

When vaccines are tested in clinical trials, thousands of participants get the vaccine and a similar number receive a placebo. The vaccine maker then waits until a minimum number of people are infected with COVID-19, and compares how many of those infected got the vaccine and how many did not.

Not enough seniors were among the group who did get infected with COVID-19 to be useful to draw conclusions in the Oxford-AstraZeneca trial. However, data on blood samples showed seniors given the vaccine did develop the antibodies to COVID-19 in similar levels to younger individuals.

Pifzer-BioNTech and Moderna both had more substantial data for older participants in the clinical trials.

Both Pfizer-BioNTech and Moderna reported about 95 per cent effectiveness at preventing COVID-19 overall, while Oxford-AstraZeneca reported its vaccine to be about 62 per cent effective.

Dr. Supriya Sharma, the chief medical adviser at Health Canada overseeing the regulatory review, said Health Canada’s authorization is not out of step with the NACI recommendations.

Sharma said Health Canada noted the concerns about clinical data but authorized the vaccine for use because the data showed the vaccine to be both safe and effective in all adults.

“I agree with the recommendation,” she said Monday in an interview with The Canadian Press.

She said the preference is for those most vulnerable to get the vaccines with the best data available, but for those who are less vulnerable, getting this vaccine now could provide a significant benefit to them and to reducing overall COVID-19 caseloads.

READ MORE: Feds hoping for AstraZeneca shots this week as Pfizer-BioNTech prepare next delivery

Mia Rabson, The Canadian Press


Like us on Facebook and follow us on Twitter.

Want to support local journalism during the pandemic? Make a donation here.

Coronavirusvaccines

Get local stories you won't find anywhere else right to your inbox.
Sign up here

Just Posted

FILE – Wet’suwet’en hereditary chiefs have agreed to sign a memorandum on rights and title with B.C. and Ottawa, but elected chiefs are demanding it be called off over lack of consultation. (Thom Barker photo)
Wet’suwet’en hereditary chiefs, Lake Babine Nation get provincial funding for land, title rights

Government says it’s a new, flexible model for future agreements between Canada, B.C. and First Nations.

Vanderhoof municipal office sign on Burrard Avenue. (Aman Parhar/Omineca Express)
Vanderhoof council discuss requests from NWRI, airport, BC Wildfire

District of Vanderhoof held their regular public meeting of council on April… Continue reading

The property on which a residential school (pictured) that was torn down years ago in Lower Post is to be the location of a cultural centre. (Indian Residential School History and Dialogue Centre photo)
Lower Post residential school building to be demolished, replaced with cultural centre

Project to be funded by federal and provincial governments, Daylu Dena Council

To send in Letters to the Editor, email aman.parhar@ominecaexpress.com
Letter: Increased aggression towards staff at Omineca Medical clinic

Dr. Davy Dhillon writes letter on behalf of the clinic

Basin Snow Water Index map for Apr. 1, 2021. (BC River Forecast Centre photo/Lakes District News)
Snowpack above normal for Upper Fraser West basin

Snowpack assessments for early April reveals above normal levels for northwestern British… Continue reading

Vancouver resident Beryl Pye was witness to a “concerning,” spontaneous dance party that spread throughout social groups at Kitsilano Beach on April 16. (Screen grab/Beryl Pye)
VIDEO: Dance party erupts at Vancouver’s Kitsilano Beach to the dismay of onlookers

‘It was a complete disregard for current COVID-19 public health orders,’ says Vancouver resident Beryl Pye

Lord Tweedsmuir’s Tremmel States-Jones jumps a player and the goal line to score a touchdown against the Kelowna Owls in 2019. The face of high school football, along with a majority of other high school sports, could significantly change if a new governance proposal is passed at the B.C. School Sports AGM May 1. (Malin Jordan)
Power struggle: New governance model proposed for B.C. high school sports

Most commissions are against the new model, but B.C. School Sports (BCSS) and its board is in favour

Pall Bearers carrying the coffin of the Duke of Edinburgh, followed by the Prince of Wales, left and Princess Anne, right, into St George’s Chapel for his funeral, at Windsor Castle, in Windsor, England, Saturday April 17, 2021. (Danny Lawson/Pool via AP)
Trudeau announces $200K donation to Duke of Edinburgh award as Prince Philip laid to rest

A tribute to the late prince’s ‘remarkable life and his selfless service,’ the Prime Minister said Saturday

B.C. homeowners are being urged to take steps to prepare for the possibility of a flood by moving equipment and other assets to higher ground. (J.R. Rardon)
‘Entire province faces risk’: B.C. citizens urged to prepare for above-average spring flooding

Larger-than-normal melting snowpack poses a threat to the province as warmer weather touches down

Vancouver-based Doubleview Gold Corp. is developing claims in an area north of Telegraph Creek that occupies an important place in Tahltan oral histories, said Chad Norman Day, president of the Tahltan Central Government. (THE CANADIAN PRESS/HO)
B.C. Indigenous nation opposes mineral exploration in culturally sensitive area

There’s “no way” the Tahltan would ever support a mine there, says Chad Norman Day, president of its central government

Stz’uminus Elder George Harris, Ladysmith Mayor Aaron Stone, and Stz’uminus Chief Roxanne Harris opened the ceremony. (Cole Schisler photo)
Symbolic red dresses rehung along B.C. highway after vandals tore them down

Leaders from Stz’uminus First Nation and the Town of Ladysmith hung new dresses on Sat. April 17

A Western toadlet crosses the centre line of Elk View Road in Chilliwack on Aug. 26, 2010. A tunnel underneath the road has since been installed to help them migrate cross the road. Saturday, April 24 is Save the Frogs Day. (Jenna Hauck/ Progress File)
Unofficial holidays: Here’s what people are celebrating for the week of April 18 to 24

Save the Frogs Day, Love Your Thighs Day and Scream Day are all coming up this week

Local carpenter Tyler Bohn embarked on a quest to create the East Sooke Treehouse, after seeing people build similar structures on a Discovery Channel show. (East Sooke Treehouse Facebook photo)
PHOTOS: B.C. carpenter builds fort inspired by TV’s ‘Treehouse Masters’

The whimsical structure features a wooden walking path, a loft, kitchen – and is now listed on Airbnb

The Attorney General’s Ministry says certain disputes may now be resolved through either a tribunal or the court system, pending its appeal of a B.C. Supreme Court decision that reduced the tribunal’s jurisdiction. (AP Photo/Mark J. Terrill)
Court of Appeal grants partial stay in ruling on B.C. auto injuries

B.C. trial lawyers challenged legislation brought in to cap minor injury awards and move smaller court disputes to the Civil Resolution Tribunal

Most Read